Drop it like it’s hot.

This large meta-analysis of over 2200 men on 23 studies of prostate ultra-hypofractionation confirms that it is max dose to the urethra—and not really anything else—that determines urethral toxicity, such that each increase of 1 Gy was associated with an 0.8% increased risk of acute G2+ toxicity and 1.0% increase in late G2+ toxicity. | Leeman, Int J Radiat Oncol Biol Phys 2021