No small matter.

The debate over the need for prophylactic cranial irradiation (PCI) and even whole brain radiation altogether for small cell lung cancer continues to grow. Here’s a great article summarizing the thoughts of many leaders in the CNS arena as well as the available data describing outcomes for focal therapy for limited SCLC brain metastases. One should also take note of important changes in the language of the NCCN Guideline for SCLC that is very favorable to the future of focal therapy. | Rusthoven, J Clin Oncol 2020