Myc drop.

In these murine models of catastrophic chromosomal events preceding medulloblastoma or glioblastoma development, Myc overamplification wasn’t sufficient for tumorigenesis but was nearly ubiquitous in the setting of DNA repair deficiency. Seems complicated. But this is the first insight into synthetic lethality being necessary for survival of brain tumors with such complex chromosomal aberrations. In other words, finding the right single target Achilles heel could bring down the whole system. | Ratnaparkhe, Nature Commun 2018