Checkpoint passed.

The same group again shows that immune checkpoint inhibition is fine during radiosurgery. What’s more interesting was the clear correlation with incidence of radionecrosis and volume of brain receiving ≥12 Gy (V12 Gy). Here the V12 Gy included the target volume and did not need to be contiguous. Risks of radionecrosis at one and two years when V12 Gy was <12 cc were 4% and 8%, when 12-20 cc were 10% and 14%, and when >20 cc were 13% and 15%. | Lehrer, Int J Radiat Oncol 2023