Robust.

It looks like microsatellite instability (MSI)-high is quite predictive of immune checkpoint inhibition efficacy for metastatic colorectal cancer with this look at outcomes across a prospective biomarker database demonstrating risk of death was more than halved (HR 0.45) with first-line ICI versus chemo, even with receipt of the former being associated with older age with worse performance status. | Quintanilha, JAMA Netw Open 2023