A+ secondary analysis.

Amidst the myriad criticisms of TARGIT-A is that the authors appear to deemphasize the prespecified primary endpoint of local control and instead reserved printed visuals for local recurrence-free survival. Critics contend this was to wash out any notable difference in local recurrence events with unrelated survival events. This group decided to provide educated guesses of local failures by essentially subtracting out survival events from LRFS events, leaving us with estimated failure events. So until the trialists cough up the real data, the official over-under on local failure at 10 years is 1.7% with external beam radiation versus 6.6% with intraop radiation alone. | Ward, Int J Radiat Oncol Biol Phys 2022