Inheritance law.

Here’s the latest ASCO / ASTRO / SSO guidelines on the niche management of hereditary breast cancers. Non-standard recommendations include therapeutic ipsilateral mastectomy for TP53 mutation carriers given the contraindication to radiation, contralateral prophylactic mastectomy for BRCA carriers, platinum agents for advanced BRCA-associated cancers, and PARP-inhibitors for metastatic HER2(-) BRCA-associated cancers. | Yip, JAMA Surg 2021