What you can’t see.

This interesting case series demonstrates that interventions to disrupt the blood brain barrier prior to are working but with some unintended consequences. Among 65 patients undergoing ophthalmologic exams following intra-arterial hypertonic mannitol intended to disrupt the tight junctions of vascular endothelial cells that form the blood-brain barrier prior to chemo, half developed maculopathy in a manner that appeared dependent on the number of infusions received. | Simonett, JAMA Ophthalmol 2020