Sentinel event.
Only a small portion of patients in the trials establishing the efficacy of sentinel node sampling (SNS) for endometrial cancer had high-grade disease. In the prospective SENTOR study (from the same Toronto medical center), 156 patients with grade 2-3 endometrial cancer underwent SNS using indocyanine green at time of minimally-invasive hysterectomy. All those with grade 2 disease (n=30) went on to have completion pelvic node dissection, and most of those with grade 3 (101/126) also had a para-aortic node dissection. Overall, 27 patients (17%) had nodal disease pathologically detected, of whom 26 patients had involved sentinel nodes. TBL: Sentinel node sampling for grade 2-3 endometrial cancer has a sensitivity of 96%, a false-negative rate of 4%, and a negative predictive value of 99%, making it an effective stand-alone tool for endometrial cancer nodal staging. | Cusimano, JAMA Surg 2020
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