Germinal theory.
Our understanding of the role of B-cells in anti-tumor immunity continues to expand. Tertiary lymphoid structures in the tumor microenvironment, for instance, are associated with better response to immunotherapy. This study demonstrates the presence of active HPV-specific B-cell responses (including developing germinal centers) in head and neck tumor stroma. Here’s to exploring how to harness adaptive anti-tumor immunity to improve treatment outcomes. | Wieland, Nature 2020
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