Systematic.
This international retrospective pooled analysis included 166 women with breast cancer achieving at least a partial clinical response to neoadjuvant chemo followed by image-guided breast biopsies and then surgery. The false negative rate of pre-surgical biopsies was 18% overall, but only 3% when the post-chemo tumor bed was ≤2 cm and ≥6 biopsies were performed (n=76). | Tasoulis, JAMA Surg 2020
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