Important checkpoint.
The survival impact of adding CDK4/6-inhibitors to endocrine therapy for metastatic hormone receptor(+) breast cancer has seen mixed results across the myriad trials recently and currently underway. In an attempt to clear things up, this meta-analysis of 9 trials with over 5K enrollees demonstrates a significant improvement in overall survival with the addition of CDK4/6-inhibition, which held true across virtually every possible subgroup. | Li, JAMA Netw Open 2020
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