Change is the only constant.

Non-small cell lung cancer (NSCLC) notoriously becomes more molecularly heterogeneous throughout treatment. Here’s a fascinating look at the complexity of the vastly changing molecular landscape of NSCLC when single-cell RNA sequencing is longitudinally performed on tumor samples from the same patients (1) prior to treatment, (2) while on treatment with good clinical response, and (3) upon clinical progression. | Maynard, Cell 2020