Why wait.
Since PACIFIC, immune checkpoint inhibition (ICI) following definitive chemoradiation for locally-advanced non-small cell lung cancer (NSCLC) has become standard. This phase 1 trial paves the road for earlier integration of ICI into the treatment algorithm with “no dose-limiting toxicities” among 21 patients receiving pembro concurrent to standard chemoradiation for unresectable stage III NSCLC...although there was one case of grade 5 pneumonitis that hopefully doesn’t serve as a harbinger for others in bigger trials to come. | Jabbour, JAMA Oncol 2020
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