Sperm check.

As feared, there is now evidence that immune checkpoint inhibitors hinder spermatogenesis. And it comes in the form of another Hopkins autopsy study. Among 13 men who died with Stage IV melanoma, 7 received ICI and 6 (86%) of them had pathologic evidence of impaired spermatogenesis compared to only 2 (33%) of the others. | Scovell, JAMA Oncol 2020