SCCUP work.

When it comes to head and neck squamous cell carcinoma of unknown primary (SCCUP), it can be tough to feel confident in your treatment decisions. That’s because shifts in disease etiology and changes in treatment technique have made those decisions more nuanced than just treating all mucosal sites and bilateral neck. Here are the ASCO expert consensus guidelines for the management of SCCUP. It a great step-by-step guide on workup, surgical management, and radiation/chemotherapy. The radiation section is thorough and gives concrete mucosal site coverage recs based on histological characteristics and nodal sites. By carefully considering the nodal levels involved, as well as HPV and EBV status, one can almost always narrow mucosal coverage to a single site (i.e. oropharynx, nasopharynx, or larynx/hypopharynx). TBL: The ASCO consensus guidelines are a great resource to optimize management of SCCUP. | Maghami, J Clin Oncol 2020