Flash points.

The latest review on FLASH-RT further supports the hypoxia hype as the lynchpin of its radiobiological M.O. for widening radiation’s therapeutic index by 2- to 3-fold. Additional salient points include that (1) hypoxic tumors are notoriously radioresistant so we’ve yet to explain why tumors remain sensitive to FLASH-RT and, in fact, (2) there are no studies reporting long-term tumor control after FLASH-RT in animal models. | Hendry, Int J Radiat Oncol Biol Phys 2020