Don’t be so quick to hop on.

We were a little late on this one, but, in the randomized HOPON trial of over 100 patients with prior radiation (of at least 50 Gy) to the mandible undergoing high-risk dental procedures, there was no benefit to prophylactic hyperbaric oxygen. The rate of osteoradionecrosis at 6 months was 6% in both arms. This gives even less enthusiasm to its routine use to prevent complications. | Shaw, Int J Radiat Oncol Biol Phys 2019