An offensive protuberance.

Dermatofibrosarcoma protuberans (DFSP) almost always harbors a Philadelphia chromosome-like translocation involving PDGFβ, so it makes since that it would respond to imatinib. This large meta-analysis demonstrates an impressive overall response rate of >60%, making it a great choice for disfiguring tumors. | Navarrete-Dechent, JAMA Dermatol 2019