Sugar high.

PI3K-alpha inhibitors haven’t taken off like the related PI3K-delta inhibitors, and a novel study indicates it’s due to an unintended upregulation in glucose and insulin with the former. This in turn upregulates the PI3K pathway in the face of its “inhibitors.” The answer? To take your PI3K-alpha inhibitor on a ketogenic diet, of course. | Hopkins, Nature 2018