Germlines done WNT crazy.

A huge international genetic analysis of blood samples from >1K patients with medulloblastoma and >53K controls demonstrated that germline mutations were responsible for 6% of medullos analyzed retrospectively (n=673), validated by the 5% rate among those analyzed prospectively (n=349). Rates differed significantly across the recognized four molecular subtypes—WNT (6-8%), SHH (14-20%), Group 3 (1-2%), and Group 4 (0-2%)—suggesting germline sequencing is warranted for patients with the SHH and probably WNT subtypes. | Waszak, Lancet Oncol 2018